Relationships between serum leptin level and severity of positive symptoms in schizophrenia

Authors: Takayanagi Y, Cascella NG, Santora D, Gregory PE, Sawa A, Eaton WW.

The adipocytokine leptin is a key mediator of energy homeostasis. Recent papers have suggested that leptin may also have roles in the brain however it is unclear whether leptin is connected to symptoms of mental disorders. In this study, we sought to clarify the relationships between serum leptin level and psychopathology in schizophrenia (SZ) patients. The severity of positive symptoms inversely correlated with the serum leptin levels among SZ patients. There was no correlation between leptin levels and negative symptoms or neurocognition. Our data suggest a role of leptin in SZ positive symptoms.

Full text and source: Science Direct

Neurosci Res. 2013 Jul 26. pii: S0168-0102(13)00180-6. doi: 10.1016/j.neures.2013.07.003.

Copyright © 2013. Published by Elsevier Ireland Ltd.